Abstract
The indiscriminate administration of ready-to-use herbal formulations has become a major concern due to their potential health risk. The study investigated the effect of class bitters® (CB) - a polyherbal formula prepared with Mondia whitei, Khaya senegalensis, Capparis erythrocarpus, Thoningia sanguinea and Xylopia aethiopica on serum electrolytes and hematological parameters in male Wistar albino rats. Two doses (500 and 1000 mg kg–1) of the polyherbal drugs were administered orally to male Wistar albino rats for a period of 9 weeks. The results showed that administration of 500 and 1000 mg kg–1 body weight of CB recorded a marked increase in the levels of sodium and chlorum when compared with control. However, there was a marked reduction in the levels of potassium and hydrogen carbonate. The results of the study also showed a significant (P≤0.05) decrease in the level of hematological parameters such as hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs) and platelets levels in the male Wistar albino rats, when compared with control. The marked decrease in Hb, PCV, RBCs and platelets concentrations observed in experimental rats in this study suggest that CB may have an adverse effect on erythropoiesis. These observations therefore showed that long-term administration of CB might cause renal disease and anemia.
Highlights
Introduction use of some herbal medicines5 Recent child birth to arrest bleeding owing to his antiresearch revealed that adverse reactions to septic properties.[18]
The seed and mental rats in this study suggest that Class bitters® (CB) may health, it is necessary to ensure that all medi- juice of pounded leaves of Capparis erythrocarhave an adverse effect on erythropoiesis. cines, including unlicensed products, are safe pus are used against child convulsive fever and
Class bitters® (CB) is a herbal materials, herbal preparations and fin- ous generations and it is these types of toxicity polyherbal formula produced by Classic Herbal ished herbal products that contain parts of that are of most concern when assessing the Centre in Accra, Ghana
Summary
At the end of the treatment period, the animals were weighed and sacrificed using cervical dislocation method. Results of the study showed that administration of 500 and 1000 mg kg–1 b.w. of CB recorded a significant (P≤0.05) decrease in the levels of hemoglobin (Hb), packed cell volume (PCV), red blood cells (RBCs), WBC, neutrophil and study. They were purchased from a local herbal obtained by cardiac puncture using 2 mL hypo- platelets when compared with control with the drug retailer in Rumuola, Port Harcourt, Rivers dermal syringe. A total of 30 male Wistar albino rats weighing between 140 to 160 g used in this study ly were obtained from the Animal House of the Department of Biochemistry, University of Port n Harcourt, Choba, Rivers State, Nigeria. The auto counter utilized 20 mL of blood in 4.5 mL of a commercially prepared diluent
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