Abstract
Objective: Potassium dichromate (K 2 Cr 2 O 7 ) is a potent pollutant for human and animal health. The purpose of the current work is to compare the effect of K 2 Cr 2 O 7 using variations in the dose, route of administration and duration of exposure in male and female Wistar albino rats and to research the interaction of chromium and selenium with a special focus on hematopoiesis. Materials and methods: K 2 Cr 2 O 7 was subcutaneously administered alone (10, 50 and 100 mg/kg body weight) or K 2 Cr 2 O 7 (10 mg/kg) in association with selenium (0.3 mg/kg) was administered to female Wistar albino rats. Male rats received in their drinking water K 2 Cr 2 O 7 (30 mg/L/day) alone or in association with Se (0.3 mg/L/day) for 20 consecutive days. The hematological parameters were evaluated on days 3, 6 and 21 after subcutaneous (sc.) treatment in female rats and on days 10 and 20 after oral administration in male rats. Results: K 2 Cr 2 O 7− induced during the first three days a significant ( p Conclusion: These results suggest that the selenium has a protective role against the hematotoxicity of subcutaneous chromium in female Wistar rats.
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