Abstract
Methods 29 children (17 boys and 12 girls), aged from 14 days to 17 years old with different CHD underwent content analysis of following toxic substances: Al, Cd, Pb, Hg, Be, Ba, Tl, Bi, As, Ni, Sb , Sn, Sr, Ti, W, Zr, Ag, Li, B, Co, Si, V in intraoperative (23) and autopsy (6) biopsy tissue samples of heart (n=37) and great vessels (n=18) by atomic emission and absorption spectrometry methods in inductively coupled plasma. Study received an approval of ethic committee of the clinic.
Highlights
According to experimental data, numerous substances have ability to pass through the placental barrier and disrupt cardiogenesis
The aim of this research was to study the level of toxic substances content in heart tissue samples of children with CHD
Our results indicate that, children with CHD have a special elevated set of specific toxic substances at the site of malformation
Summary
Numerous substances (including toxic, potentially toxic, conditionally essential chemical elements) have ability to pass through the placental barrier and disrupt cardiogenesis.
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