Abstract

Metabolic P systems are a modeling framework for metabolic, regulatory and signaling processes. The synthesis of flux regulation functions from time series of substance concentrations is a key task for reverse-engineering biological systems by MP systems. In this paper we present some important improvements to a technique based on genetic algorithms and multiple linear regression for the synthesis of regulation functions. An accurate analysis of generated functions, for the case study of the mitotic oscillator in early amphibian embryos, shows that some knowledge about the regulation mechanisms of biological processes can be inferred from experimental data using this methodology.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.