Abstract
Nanoparticle-based drugs are rapidly evolving to treat different conditions and have considerable potential. A new system based on the combination of electrical impedance tomography (EIT) imaging and a power amplifier with a RF coil has been developed to study the effect of gold nanoparticles (AuNPs) when excited in the MHz frequency range. We show that samples including AuNPs have a temperature increase of 1–1.5 °C due to the presence of RF excitation at 13.56 MHz which provides a higher rate of change for solutions without AuNPs. They also show more than a 50% increase in conductivity in difference imaging as the result of this excitation. The change for samples without AuNPs is 40%.
Highlights
IntroductionWhereby therapeutic agents are transported from the site of administration to diseased tissues, is of prime concern in pharmaceutical research
Targeted drug delivery, whereby therapeutic agents are transported from the site of administration to diseased tissues, is of prime concern in pharmaceutical research
The results demonstrate that it is possible to excite 5 nm AuNPs at 13.56 MHz and image them with electrical impedance tomography (EIT)
Summary
Whereby therapeutic agents are transported from the site of administration to diseased tissues, is of prime concern in pharmaceutical research. This concept has significant potential in oncology where chemotherapeutic drugs with a narrow range between effective and toxic doses can compromise the efficacy of the treatment. Image-guided drug delivery, which leverages clinical imaging modalities for the guidance of DDS, has emerged as a viable strategy for enhancement of targeted, personalized drug therapies. In this drug delivery paradigm, imaging may be used to identify the target and non-target anatomy or for screening, planning, monitoring, and post-procedural assessment of treatment outcome [1,2]
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