Abstract
Toward A Transgenic Dog as a Human Disease Model
Highlights
Even though transgenic mouse models have been widely used as disease models in biomedical research, organs size, genetic and physiological differences between human and rodents have put limitations on applying the rodents study to the human [1,2]
Those who interested in obtaining canine clones and expect a perfect phenotypic copy should be made aware of the diversity of phenotypes that may occur in animals obtained from donor cells with the same genotype
In canine Somatic Cell Nuclear Transfer (SCNT), cloned dogs were generated by nuclear transfer using Canine Adipose-Derived Mesenchymal Stem Cells (cASCs) [32], these outcomes suggest that cASCs could be a useful tool as nuclear donor cells for SCNT as well as clinical applications
Summary
Even though transgenic mouse models have been widely used as disease models in biomedical research, organs size, genetic and physiological differences between human and rodents have put limitations on applying the rodents study to the human [1,2]. Recent successes in creating transgenic animals [14,15,16,17,18,19] using Somatic Cell Nuclear Transfer (SCNT) technique which targeted modification of the genome of the donor cells gave promise to future generation of genetically modified models in large animal including dogs [20,21]. The transgenic cloned animals of having identical genomic background are extremely valuable for biomedical research, in which the transgenic SCNT technique is worth enough Those who interested in obtaining canine clones and expect a perfect phenotypic copy should be made aware of the diversity of phenotypes that may occur in animals obtained from donor cells with the same genotype. In canine SCNT, cloned dogs were generated by nuclear transfer using cASC [32], these outcomes suggest that cASCs could be a useful tool as nuclear donor cells for SCNT as well as clinical applications
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