Abstract
Comprehensive SummarySepositoside A (1) is a prototypical cyclic steroid glycoside bearing a hybrid 16‐membered ring composed of the steroid skeleton and a 1,2‐trans‐linked trisaccharide. Herein, we report an expedient access toward two simplified analogues, in which the strained 16‐membered ring is constructed via Au(I)‐catalyzed intramolecular addition of alcohol to epoxide. A similar macroetherification in relevant steroid trisaccharides has been intensively examined, however, failed to furnish the macrocyclic skeleton of Sepositoside A.
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