Abstract
Divergent protein engineering of the natural transaminase Vf‐ω‐TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% ee). More details are discussed in the article by Zhong et al. on pages 2335—2340.image
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