Abstract

The total synthesis of 12-membered macrolides, patulolide C, 11-epipatulolide C and formal synthesis of patulolide A and epipatulolide A, starting from 1,8-octane diol is reported. A combination of Jacobsen’s hydrolytic kinetic resolution and Sharpless epoxidation is used for the creation of two stereogenic centres, while ring-closing metathesis strategy was used for the construction of the lactone ring.

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