Abstract
The total synthesis of 16-membered macrolides, macraosphelides I and G, has been achieved starting from ethyl-( S)-lactate and ( S)-malic acid. A combination of Jacobsen’s hydrolytic kinetic resolution and Sharpless epoxidation is used for the creation of two stereogenic centres, while Yamaguchi esterification and ring-closing metathesis strategies were used for the construction of the lactone ring.
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