Total synthesis of (+)-massarinolin B and (+)-4- epi-massarinolin B, fungal metabolites from Massarina tunicata

Abstract

The Cr(II)- and Ni(II)-mediated coupling of several tricyclic chiral aldehydes with ( E)-β-iodomethacrylates (Nozaki–Hiyama–Kishi reaction) was successfully applied to the preparation of some valuable key intermediates of our synthetic strategy to the fungal metabolites (+)-massarinolin B, (+)-4- epi-massarinolin B and (+)-massarinolin C.