Abstract
An expeditious access to marine natural products (+)-strongylin A and corallidictyal D is described. A TFA/Et3SiH-induced reductive isomerization of enols I to alkenyl benzenes II followed by a selectivity-controlled cyclization in the presence of HCl and BF3·Et2O affords benzofuran III and benzopyran IV, respectively. The applicability of this HCl-induced cyclization is showcased by a regio- and stereoselective synthesis of corallidictyal D, while BF3·Et2O-promoted cyclization posterior to rearrangement of an alkenyl benzene provides a regioselectively different benzopyran, (+)-strongylin A.
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