Handbook of Marine Natural Products

Abstract

Introduction (Fattorusso and Taglialatela-Scafati) Section I: Natural Product Trends in Different Groups of Marine Life 1.1. Taxonomy and marine natural products research (J. Blunt) 1.2. Chemistry of microalgae and macroalgae (Gerwick) 1.3. Chemistry of marine bacteria and fungi (W. Fenical) 1.4. Chemistry of marine invertebrates (sponges) (P. Proksch) 1.5. Chemistry of marine invertebrates (tunicates) (M. Menna) Section II: Structure Elucidation of Marine Natural Products 2.1. The role of databases in marine natural products research (M. Munro) 2.2. Strategies for structural assignment of MNP through advanced 2D NMR techniques. (A. Mangoni) 2.3. Configuration assignment of marine natural products (K. Gustafson) 2.4. Prediction of NMR data through quantum-mechanical calculations (R. Riccio) 2.5. Contemporary Strategies in Natural Products Structure Elucidation (P. Crews) Section III: MNP and Chemical Ecology 3.1. Antipredatory defensive role of natural products from marine invertebrates (J. Pawlik) 3.2. Antipredatory defensive roles of planktonic MNPs (A. Ianora) 3.3. Anti-fouling activity of MNP (P. Qian) 3.4. Chemical interactions among marine competitors, and host-pathogens (M. Slattery) 3.5. Marine Metabolites and Metal Ion Chelation (M. Jaspars) Section IV: Biosynthesis of MNP 4.1. Biosynthetic studies through feeding experiments (G. Cimino) 4.2. Biosynthetic studies through molecular genetic approaches (D. Sherman) 4.3. Mechanisms of halogenation of marine secondary metabolites (G. Koenig) Section V: Biomedical Potential of Marine Natural Products 5.1. Enzyme Inhibitors from Marine Invertebrates (N. Fusetani) 5.2. Marine Natural Products that target Microtubules (R.J. Andersen) 5.3. Antiprotozoan Marine Natural Products (Fattorusso and Taglialatela Scafati) 5.5. Mechanism-based screening for cancer therapeutics with examples from the discovery of marine natural product-based HIF-1 inhibitors (D. G. Nagle) 5.6. Fluorescent proteins from the oceans: Marine macromolecules of utility to medicine and biotechnology (J. Wiedenmann) <5.7. From biosilica of sponges to fabricated biomedical materials (W.E.G. Muller) 5.8. Meeting the supply needs of marine natural products (D.J. Newmann) 5.9. Legal and ethical issues involving marine biodiscovery and development (G.M. Cragg) 5.10. Synthesis of Marine Natural Product Leads (A. Phillips) Section VI: Marine Toxins: A Problem for Public Health and Seafood Resources 6.1 Seafood toxins: classes, sources and toxicology (P. Ciminiello) 6.2. Detection of marine toxins through LC/MS techniques (M. Quilliam) 6.3. Marine protein toxins (H. Nagai) Conclusions. The future of marine natural products chemistry. (W. Gerwick)