Abstract
AbstractThe enantioselective total synthesis of the biologically active 1,4‐benzodioxane lignans isoamericanin A (2) and isoamericanol A (3) has been achieved in 11 and 12 steps, respectively. These benzodioxane lignan natural products, and others that contain 9‐hydroxymethyl group, show a wide range of biological properties. The 1,4‐benzodioxane ring was formed by an acid‐catalysed cyclisation, which gave the desired trans isomer exclusively. This method will allow the synthesis of a number of benzodioxane compounds containing a 9‐hydroxymethyl group
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