Total Synthesis Involving a Stereoselective Photoredox Step

Abstract

Stereoselective reactions are fundamental chemical transformations in total synthesis. Whereas many stereoselective ionic reactions are available, well understood and predictable, stereoselective free-radical reactions are less known. Although important advances were made by Curran, Porter, Sibi, Renaud and others the emergence of photoredox catalysis has recently favored the development of new stereoselective radical procedures under mild reaction conditions. Consequently, more total syntheses of natural products have been achieved in recent years. In this chapter, we selected the contribution of outstanding researchers which have developed and taking advantage of stereoselective photoredox reactions and applied on their total syntheses. Accordingly, total syntheses in which a specific photoredox reaction is highlighted, are discussed in this book chapter.