Total Syntheses of FR901464

Abstract

Three total syntheses of potent anticancer natural product FR901464 are described. The first total synthesis by the Jacobsen group used transition metal-catalyzed reactions to prepare their chiral fragments. Subsequently, the Kitahara group described their synthesis using the chiral pool to construct their building blocks. Finally, the Koide group published the most recent synthesis of FR901464 using both asymmetric reactions and the chiral pool for their chiral fragment syntheses. It is envisioned that these total syntheses will assist biological studies of FR901464 and its unique mode of action.