Total plasma sulfide in mild to moderate diastolic heart dysfunction

Nina Glavnik Poznič ,Tomaž Goslar ,Tomaž Marš ,Matej Podbregar ,Damir Kovačić

doi:10.22514/sv142.102018.5

Abstract

mechanisms of diastolic dysfunction are not understood well. Hydrogen sulfide is an important endogenous gaseous trans-mitter that can influence heart remodeling. The aim was to determine total plasma sulfide (TPS) levels, as a surrogate marker of hydrogen sulfide, in patients with mild diastolic dysfunction.Methods. Total plasma sulfide and N-ter-minal pro brain-type natriuretic peptide (NT-proBNP) levels were determined in ambulatory patients with arterial hyper-tension or diabetes mellitus and echocar-diographically mild to moderate diastolic dysfunction.Results. Twenty-four patients were in-cluded: nine with normal diastolic func-tion (Grade 0), eight with an impaired relaxation pattern (Grade 1), and seven with a pseudo-normalized pattern (Grade 2). TPS levels were highest in patients with normal diastolic function (Grade 0), and lowest in patients with Grade 2 diastolic dysfunction, with this difference between Grade 0 and Grade 2 showing statistical significance (p = 0.017). NT-proBNP lev-els showed the reverse behavior, with this difference again showing statistical signifi-cance (p = 0.042).Conclusions. Total plasma sulfide levels decrease with worsening of diastolic func-tion from normal to moderate diastolic dysfunction.&nbsp

Highlights

Heart failure with preserved ejection fraction is a new condition that has only been described in recent years. [1] One of its defining criteria is diastolic dysfunction
total plasma sulfide (TPS) levels were highest in patients with normal diastolic function (Grade 0), and lowest in patients with Grade 2 diastolic dysfunction, with this difference between Grade 0 and Grade 2 showing statistical significance (p = 0.017)
The data for the TPS and NT-proBNP levels according to the diastolic function of the different patients groups are presented in table 3

Summary

Introduction

Heart failure with preserved ejection fraction is a new condition that has only been described in recent years. [1] One of its defining criteria is diastolic dysfunction. Insufficient diastolic relaxation results in higher left ventricular filling pressure, left atrial stretch, and pulmonary congestion All of these represent the exercise dyspnea and signs of pulmonary congestion seen in cases of advanced heart failure. The aim of the current study was to determine the levels of TPS and N-terminal pro brain-type natriuretic peptide (NTproBNP) in ambulatory hypertensive or diabetic patients with mild to moderate diastolic dysfunction and no clinical signs of pulmonary congestion. The aim was to determine total plasma sulfide (TPS) levels, as a surrogate marker of hydrogen sulfide, in patients with mild diastolic dysfunction. Total plasma sulfide and N-terminal pro brain-type natriuretic peptide (NT-proBNP) levels were determined in ambulatory patients with arterial hypertension or diabetes mellitus and echocardiographically mild to moderate diastolic dysfunction.

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Conclusion