Abstract
Background: Urinary tract stones are one of the most common causes of kidney disease. There is evidence for the possible involvement of oxidative stress in the formation of kidney stones and renal cell injury. Objectives: In this study, we aimed to determine the total antioxidant capacity (TAC), malondialdehyde (MDA), serum thiol group, ceruloplasmin (CP) levels and catalase (CAT) activity in the serum of the patients with kidney stones. Materials and Methods: This study was conducted as a case-control study. A total of 31 patients (16 males and 15 females) with kidney stone(s) and a comparative normal control group including 21 (12 males and 9 females) healthy subjects were included. Results: The present study revealed that TAC level was significantly higher in the control group (P=0.004), and the mean thiol group was remarkably decreased in the patient group (P<0.001). Moreover, CAT activity decreased in the patients but it was not significant (P=0.23). On the other hand, the findings showed that the serum CP level significantly increased in the patient group (P<0.001). MDA level also increased in the patient group, although this increment was not significant (P=0.87). Conclusions: It can be concluded that the reduction of antioxidant indices in the patients with kidney stones can damage the renal tubular cells and strengthen the accumulation of crystals and the formation of kidney stones.
Highlights
Urinary tract stones are one of the most common causes of kidney disease
The findings showed that the MDA level increased in the patient group compared to the control group, but this increase was not statistically significant (P = 0.87)
The serum CP level significantly increased in the patient group (P < 0.001)
Summary
Urinary tract stones are one of the most common causes of kidney disease. Objectives: In this study, we aimed to determine the total antioxidant capacity (TAC), malondialdehyde (MDA), serum thiol group, ceruloplasmin (CP) levels and catalase (CAT) activity in the serum of the patients with kidney stones. A total of 31 patients (16 males and 15 females) with kidney stone(s) and a comparative normal control group including 21 (12 males and 9 females) healthy subjects were included. Urinary tract stone is the most common cause of kidney disease and poses a remarkable health care burden on adults. Recent studies have shown that nutrition, lifestyle factors, and metabolic factors are instances of the most important factors involved in developing kidney stones [3,4]. The disease is more common among the people aged 30-60 years and, more common to men than to women [3]
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