TosMIC and its derivatives as versatile sulfonylating agents for the synthesis of p-toluenesulfonylarenes from aryl halides and arylboronic acids

Abstract

An efficient copper(II) catalyzed sulfonyation of aryl halides has been achieved using TosMIC ( p -toluenesulfonylmethyl isocyanide) as a sulfonylating agent. This newly developed sulfonylation approach provides an easy access for the synthesis of diaryl sulfones from aryl bromides, iodides and boronic acids with TosMIC under neutral conditions. This method is useful for the sulfonylation of aryl boronic acids under similar conditions. This is the first report on the sulfonylation of aryl bromides, iodides and boronic acids using TosMIC. • First report on the sulfonylation of aryl bromides & iodides with TosMIC. • This method is useful for the synthesis of diaryl sulfones. • It also works with aryl boronic acids. • This method works with a diverse range of aryl halides and boronic acids.