Abstract
Aims/Purpose: To assess the antiseptic properties of Sevoflurane (SF) when topically applied to the ocular surface in an animal model, and to compare the results with that of 5% Povidone Iodine (PY), a commonly used ophthalmic antiseptic.Methods: This randomized clinical trial involved 24 eyes from 12 New Zealand white rabbits, which were divided into two groups: SF (n = 12) and PY (n = 12), based on the substance administered. Prior to the application of any agent, baseline samples were collected from the conjunctival sac of each eye to determine the normal conjunctival flora. Subsequently, a single dose of 0.1 mL of either SF or PY was administered according to the group allocation. Conjunctival sac samples were then taken at 5 and 30 minutes post‐application. The collected samples were subjected to microbiological analysis.Results: At the commencement of the study, Moraxella cuniculi was identified as the predominant species, with a statistically significant higher colony‐forming units per milliliter (CFU/mL) compared to other species (p < 0.001). In the SF group, there was a statistically significant reduction in CFU/mL for both Moraxella cuniculi and Staphylococcus aureus following treatment. Conversely, in the PY group, a significant reduction was observed only for Moraxella cuniculi. Comparative analysis between the SF and PY groups revealed no statistically significant differences in the reduction of CFU/mL for Moraxella cuniculi at any time point during the study (p > 0.05).Conclusions: Topical application of SF effectively reduces the CFU/mL of predominant germs on the ocular surface of albino rabbits, yielding results comparable to those achieved with PY.
Published Version
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