Abstract
The equatorial current of the frog lens was studied with microelectrodes and a vibrating probe. Norepinephrine, isoproterenol and terbutaline applied topically at the surface of the cornea as a 1% solution increased the equatorial current of the lens about 80%. This increase was blocked by timolol. Topical forskolin increased the equatorial current by over 80 %. This effect of forskolin was not blocked by timolol. These substances did not affect the equatorial current of the lens when the lens was suspended in a frog Ringers solution. 8-Bromo cyclic AMP increased the equatorial current when it was applied topically but not when it was added directly to the medium bathing an isolated lens. The results suggest that β-adrenergic agonists, applied topically to the cornea, increase the equatorial current of the lens by a mechanism that is mediated by cyclic AMP. The finding that 8-bromo cyclic AMP did not act directly on the lens suggests that a currently unknown substance or process is active at the level of the lens.
Published Version
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