Topical application of lidocaine or bupivacaine in the healing of surgical wounds in dogs

Bruno Watanabe Minto,Laura Zanato,Elizabeth Regina Carvalho,Camila Potério Borsaro,Josiane Morais Pazzini,Andresa Matsui,Fernando Yoiti Kitamura Kawamoto,Guilherme Galhardo Franco

doi:10.1590/s0102-865020200070000001

Bruno Watanabe Minto, Laura Zanato + Show 6 more

Open Access

https://doi.org/10.1590/s0102-865020200070000001

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Abstract

Purpose:To analyze the anesthetic drugs interference with wound healing when used in the surgical bed.Methods:Macro and microscopic aspects of healing of surgical wounds were evaluated after instillation of topical anesthetics without vasoconstrictor or saline solution 0.9% as control in the transsurgical period. Thirty dogs, males and females were divided into two experimental groups. In both groups, two circular punch lesions of 6 mm diameter were performed in the abdomen. In group 1, lidocaine was instilled in one of the lesions and saline solution in the contralateral lesion. In group 2 the procedure was repeated with the use of bupivacaine. The macroscopic assessment of the lesions was performed on the first, third and tenth postoperative day. The excisional biopsy was performed on the tenth day and the samples were submitted for histopathological examination.Results:The macroscopic analysis had a significant difference between groups. Microscopic analysis was not significant between groups.Conclusions:The topical application of lidocaine and bupivacaine in the surgical wound is feasible and it does not influence skin healing. The benefit of such a practice, which has been the subject of other studies, seems to outweigh the risks.

Highlights

In the face of scientific, clinical and economic interests, wound healing is the subject of several studies and current research[1,2].Normal healing is a complex and multifaceted process that involves continuous exchange of information between cells and the extracellular matrix[1]
The procedures of this study were performed at the “Governador Laudo Natel” Veterinary Hospital of the Faculty of Agrarian and Veterinary Sciences (FCAV), Universidade Estadual Paulista (UNESP), campus Jaboticabal
Patients were recruited from the service routine of the Teaching Hospital of the Faculty of Agricultural Sciences -FCAV / UNESP, and the Zoonosis Control Center and Animal Protection Association (APA) site

Summary

Introduction

In the face of scientific, clinical and economic interests, wound healing is the subject of several studies and current research[1,2]. Normal healing is a complex and multifaceted process that involves continuous exchange of information between cells and the extracellular matrix[1]. This exchange of information occurs through the interaction between cells and between them and the matrix. This process occurs through direct contact or through chemical compounds. Most of the compounds involved in communication in the healing process are cytokines, soluble proteins secreted by cells and growth factors[2,3]. The type, size, depth and location of the wound, apposition of the edges, contamination, vascular supply, movement and metabolic and nutritional conditions of the patient, exemplify the main ones[3]

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