Abstract
To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats. One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each: the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis. No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026). The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.
Highlights
The prevalence of chronic wounds in the general population is relatively high
Six animals in the control group and four in the experimental group died during the study due to adverse conditions, but the loss of these animals did not affect the statistical analysis of data
The experimental group showed significantly lower wound contraction rates compared with the control group on day 21 (p=0.029)
Summary
The prevalence of chronic wounds in the general population is relatively high. This condition is associated with several diseases and imposes a major social and economic burden on patients and healthcare systems. There are many treatment options for chronic wounds in the market, but it has been difficult to properly determine the cost-benefit relationship and best treatment option for each type of ulceration. There are many treatment options for chronic wounds in the market, but it has been difficult to properly determine the cost-benefit relationship and best treatment option for each type of ulceration3 Due to their antibacterial and anti-inflammatory properties, proteolytic enzymes have been used as gels or creams applied to necrotic or granular tissues in the treatment of different types of wounds. These enzymes promote the chemical debridement of the wound, increase the tensile strength of scar tissue, and stimulate re-epithelialization and formation of granulation tissue at all phases of wound healing by secondary intention. Collagenase and papain are the most commonly used debriding enzymes, and collagenase was observed to be more tolerant when used in combination with antimicrobial dressings than papain
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
