Abstract
Toll-Like Receptor Signaling in Liver Diseases
Highlights
In the present special issue of Toll-Like Receptor Signaling in Liver Diseases, the most recent advances in Toll-like receptors (TLRs) research in the liver are reviewed by worldwide authorities of liver TLR research
Subsequent studies for TLRs have focused on infectious diseases, since TLRs recognize pathogen-associated molecular patterns (PAMPs) and induce strong responses for host defense
Endogenous TLR ligands released from dying and/or damaged cells were identified. These studies have extended the idea that TLR signaling is activated in the absence of exogenous pathogens and in general sense “danger signals” to alert the host of either exogenous or endogenous “danger.”
Summary
In the present special issue of Toll-Like Receptor Signaling in Liver Diseases, the most recent advances in TLR research in the liver are reviewed by worldwide authorities of liver TLR research. Editorial Toll-Like Receptor Signaling in Liver Diseases Hepatic nonimmune cells express TLRs and respond to TLR ligands to induce innate immune responses including cytokine and type I IFN production. Upon breakdown of this regulation, inflammation is induced through innate immune responses including TLR signaling in the liver.
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