Abstract
It has been recently suggested that tolerance to the analgesic effects of low doses of morphine may be mediated by learning. The present study examines the generality of this hypothesis to both higher doses of morphine and to morphine effects other than analgesia. In the first experiment the LD50 dose of morphine was determined. The second experiment then examined the role of learning in the tolerance developed to a lethal dose of morphine by determining whether any possible learned associations between environmental stimuli and morphine injections could be extinguished. It was concluded that learning does not mediate the tolerance which can be developed to a lethal dose of morphine.
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