TOLERABILITY OF VARIOUS ANTIHYPERTENSIVE COMBINATIONS

Abstract

Aim. To compare tolerability of various antihypertensive combinations in patients with arterial hypertension (HT). Material and methods. 140 patients with HT with history of non-effective antihypertensive therapy were randomized in 4 groups, 35 patients in each. Patients of group A received indapamide retard/perindopril; group B - indapamide retard/amlodipine; group C – amlodipine/lisinopril; group D – amlodipine/bisoprolol. Therapy duration was 12 weeks. Results. 28 (20%) patients dropped out of the study. All antihypertensive combinations significantly decreased blood pressure level. Patients of group A did not stop therapy because of adverse events. 6 (17,1%) dropped out of the study because of ineffective therapy in maximal doses and therapy rejection. Palpitation was a reason of drug withdraw￾al in 3 (8,6%) of 8 (22,9%) dropped patients of group B. Low limb edema was a reason of drug withdrawal in 4 (11,4%) of 8 (22,9%) dropped patients of group D. Cough was a reason of drug withdrawal in 4 (11,4%) of 5 dropped patients of group C. Dose reduction was needed in some patients of all groups because of hypotension. Conclusion. The adverse events were observed in 25% of patients during 12 weeks of therapy. The patients received indapamide retard/amlodipine and amlodipine/bisoprolol had the highest rate of drug withdrawal because of adverse events. Low limb edema, cough and palpitation were the most frequent adverse events needed therapy withdrawal.