Abstract
Two new coumarins with a rare, oxidized geranyl group, named toddalins I (1) and J (2), were isolated from the roots of Toddalia asiatica, a traditional Chinese herb used to treat many diseases, especially athletic injuries. Their structures were determined using extensive spectroscopic methods, including 1D NMR, 2D NMR and HRESIMS. Toddalins I (1) and J (2) exhibited moderate in vitro anti-inflammatory activities by the inhibition of lipopolysaccharide (LPS)-induced NO production in RAW 264.7 macrophages with IC50 values of 12.6 and 15.6 μM, respectively.
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