To study renal parameters and serum calcium levels in birth asphyxia

Dr Amit Patidar,Dr Jagdish Chandra Mandliya,Dr Mamta Dhaneria,Dr Pavan Sonker

doi:10.17511/ijpr.2020.i06.06

Dr Amit Patidar, Dr Jagdish Chandra Mandliya + Show 2 more

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https://doi.org/10.17511/ijpr.2020.i06.06

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Background: Birth asphyxia is a common neonatal problem and contributes significantly to neonatal mortality and long term morbidity. Any organ can be affected but the brain, heart, kidneys are more sensitive to hypoxic injury. Aim and Objective: To study renal parameters and serum calcium levels in birth asphyxia, to determine the incidence of renal failure in asphyxiated newborns, and to correlate the renal parameters with different severity of birth asphyxia and with different stages of hypoxic-ischemic encephalopathy. Method and material: A comparative study of 69 term newborns, appropriate for gestational age born/admitted to tertiary care Centre RDGMC Ujjain with birth asphyxia and 69 normal newborns without birth asphyxia was done. Perinatal history, physical examinations, New Ballard score, Apgar score was done. Data collected and entered in the master chart for results and analysis. Result: The study included 69 cases and 69 controls with the majority of boys. Mild, moderate, and severe birth asphyxia was7%, 29%, and 64% of all cases respectively. The incidence of acute renal failure was 57% among cases of birth asphyxia. The incidence of acute renal failure was 53% and 50% in hypoxic-ischemic encephalopathy stages III and II respectively. Incidence of renal failure with mild, moderate, and severe asphyxia was 40%, 50%, and 39% respectively Conclusion: Perinatal asphyxia is an important cause of neonatal renal failure. Monitoring of urea, creatinine and urine output helps in the early diagnosis and management of acute renal failure

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The incidence of perinatal asphyxia is 1–1.5 % in most developed countries and is inversely related to gestational age and birth weight [1]
Male neonates had a higher incidence of birth asphyxia
The incidence of renal failure had a linear correlation with the severity of asphyxia and with the Hypoxic Ischemic Encephalopathy (HIE) stage and incidence of intrinsic renal failure increased as the severity of asphyxia and HIE staging progressed

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The incidence of perinatal asphyxia is 1–1.5 % in most developed countries and is inversely related to gestational age and birth weight [1]. The National Neonatal Perinatal Database (NNPD) 2000 used a similar definition for perinatal asphyxia It defined moderate asphyxia as slow gasping breathing or an Apgar score of 4-6 at 1 minute of age and severe asphyxia was defined as no breathing or an Apgar score of 0-3 at 1 minute of age [4]. Moderate, and severe birth asphyxia was7%, 29%, and 64% of all cases respectively. The incidence of acute renal failure was 57% among cases of birth asphyxia. The incidence of acute renal failure was 53% and 50% in hypoxic-ischemic encephalopathy stages III and II respectively. Incidence of renal failure with mild, moderate, and severe asphyxia was 40%, 50%, and 39% respectively Conclusion: Perinatal asphyxia is an important cause of neonatal renal failure. Monitoring of urea, creatinine and urine output helps in the early diagnosis and management of acute renal failure

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