To Evaluate the Hypnotic Doses of Etomidate and Propofol Using Entropy Monitor and to Determine their Hemodynamic Response During Laryngoscopy and Intubation

Abstract

Background and Aims: Aim of this study was to compare the doses of Propofol and Etomidate using Entropy Monitor and per kilogram body weight doses and hemodynamic effects of both the drugs after induction and intubation. Material and Method: Hundred patients of ASA grade I and II in the age group of 18-60, scheduled for elective surgery under general anesthesia were randomly allocated in two groups. In group A: Induction dose of Etomidate was given till Entropy reached value of 40. In group B: Induction dose of Propofol was given till Entropy reached a value of 40. The doses given in ml were noted and calculated. Hemodynamic parameters like SBP, DBP, MAP, heart rate, oxygen saturation (SpO2), end tidal carbon dioxide were noted at baseline, induction, 1 min, 2 min, 3 min, 4 min, 5 min and 10 min thereafter. Data was subjected to statistical analysis. Results: There was reduction in induction doses using Entropy guided hypnosis level. The mean dose of Etomidate according to entropy was 16.9±2.8mg (0.27mg/kg) and per kilogram body weight dose was 18.61±3.4mg (0.3mg/kg). The mean dose of Propofol according to Entropy was 108.8±17.6 mg (1.72mg/kg) and per kilogram body weight dose was 124±23.1mg (2mg/kg). Incidence of hypotension and tachycardia was more with Propofol than Etomidate Conclusion: Use of Entropy resulted in decrease in the dose of Etomidate and Propofol. Etomidate provides more hemodynamic stability than Propofol after induction and intubation.