Abstract
To Evaluate the Efficacy and Safety of Autologous Platelet Rich Fibrin Matrix in the Treatment of Non-Healing Ulcer of Various Aetiology
Highlights
This study demonstrates that Autologous Platelet Rich Fibrin Matrix (PRFM) is a safe and efficacious method for the treatment of non-healing ulcer and at the same time simple and highly cost effective method
Wound healing is an orderly set of processes culminating in closing the wound, any interference in this process at any step can lead to non-healing and when this process lasts for more than 6 weeks it is termed as a Non-Healing Ulcer (NHU) [1]
Platelet Rich Fibrin Matrix (PRFM), a generation Platelet Rich Plasma (PRP) is the latest addition which is based on the premise of slow and sustained release of growth factors [4] mimicking the natural wound healing process
Summary
Wound healing is an orderly set of processes culminating in closing the wound, any interference in this process at any step can lead to non-healing and when this process lasts for more than 6 weeks it is termed as a Non-Healing Ulcer (NHU) [1]. Newer modalities include hirudotherapy [2], follicular unit extraction [3] and transplant on the wound bed, epidermal grafting, etc. The focus has shifted on to growth factors which include therapies like recombinant growth factors and Platelet Rich Plasma (PRP). Platelet Rich Fibrin Matrix (PRFM), a generation PRP is the latest addition which is based on the premise of slow and sustained release of growth factors [4] mimicking the natural wound healing process. The concentration of platelets is higher in PRP but a study showed that, when incorporated into fibrin, the mean concentration of growth factors in the platelet concentrates was three times or more than that observed with conventional platelet-rich plasma. Giving PRFM an edge over PRP in wound healing
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