To Evaluate the Corelation between Age and Gleason Score in Patients with Prostate Cancer- A Tertiary Care Hospital Based Study

Abstract

Objective: The aim of this study is to evaluate the corelation between age and Gleason score in patients with prostate cancer. Materials and Methods: From January 2009 to December 2021, 268 Asian Pakistani men who underwent prostate biopsy and were diagnosed with Prostate Adenocarcinoma have been included in this study, The age of patients ranged from 40 years to 94 years. The indications for biopsy were suspicious digital rectal examination and abnormally high PSA. The procedure was performed either transurethrally, transperineally or transrectally, Results: A total of 268 patients were diagnosed with Prostate Adenocarcinoma, the age range was from 40 to 94 years. The median age was found as 68 years with an interquartile range of 15 years. The median Gleason score was found as 8 with an interquartile range of 7 scores. A negative weak corelation was found between the age of the patients at the time of diagnosis and the Gleason score (r= -0.013, p=0.832). Conclusion: Though there are many studies that support the existence of corelation between increasing age and Gleason Score, our study, like a couple of others, showed no association between the two and a weak positive corelation. Our conclusion of the study is that while studying the relationship between the two, other variables like PSA, DRE findings and TNM classification of the tumor are also important. Hence, more work needs to be done in this regard.