Abstract
This review is an example of the use of an animal model to try to understand the immune biology of pregnancy. A well-known model of recurrent spontaneous pregnancy loss is put in clinical, historical, and theoretical context, with emphasis on T cell biology.
Highlights
The ‘problem of viviparity’ (Medawar 1954) remains among the most fundamental questions in biology
It has been our hypothesis that understanding of critical clinical and basic biological problems can result from the iterative use of good clinical/epidemiological data and well-understood animal models (Bonney 2013)
What follows is a focused discussion of one animal model wherein female mice of the CBA/J strain mated with male mice of the DBA/2 strain experience a high rate of reproductive failure
Summary
The ‘problem of viviparity’ (Medawar 1954) remains among the most fundamental questions in biology.
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