To assess the incidence of vitamin D deficiency in patients receiving OHA, with comparison of metformin vs non-metformin groups

Abstract

If gastrointestinal symptoms from metformin use can create an environment conducive to the malabsorption of vitamin B12, it Is probable that vitamin D could also be malabsorbed. This could adversely affect treatment efficacy as well as expose certain patient populations to the risk of symptoms of vitamin D deficiency. Currently, no published studies have examined the effect of metformin on vitamin D levels in a population of patients with diabetes. Hence, this study focuses on the incidence of deficiencies of vitamin D in patients with type 2 diabetes on treatment with metformin (Biguanide) and compare with those on other OHAs.