Abstract
AbstractTMSOTf‐catalysed generation of 2,4,5‐trisubstituted imidazoles by a simple [3+2] addition reaction of azido chalcones and organic nitriles is described. This transformation generates two new C‐N bonds under mild reaction conditions. The substrate scope of the reaction is excellent with good number of vinyl azides and aromatic and aliphatic nitriles tolerating the reaction. It has been shown that the reaction can also be conducted under microwave condition successfully. These newly synthesized imidazoles are shown to exist as tautomeric mixture and the subsequent methylated as well as benzylated compounds have been obtained as a single regioisomer. The synthesised N‐methyl Imidazole derivative is a potential structural unit towards biologically active compounds.
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