T-lymphocyte Subpopulations in Patients with Respiratory Allergy

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To the Editor:We agree that the literature cited demonstrates changes in T-cell subpopulations as suggested with decreased OKT8, although unlike Justribo et al, other authors1Kus J Tse KS Enarson D Grzybowski S Chan-Yeung M Lymphocyte subpopulations in patients with allergic rhinitis.Allergy. 1984; 39: 509-514Crossref PubMed Scopus (13) Google Scholar, 2Kus J Tse KS Vedal S Chan-Yeung M Lymphocyte subpopulations in patients with allergic and nonallergic asthma.Clin Allergy. 1985; 15: 523-529Crossref PubMed Scopus (20) Google Scholar do not observe decreased OKT4 and therefore report an increased OKT4/OKT8. We would further agree that this appears to be markers of respiratory allergy and note the evidence that, with treatment of the allergy, improvement toward normal can be observed in these parameters.1Kus J Tse KS Enarson D Grzybowski S Chan-Yeung M Lymphocyte subpopulations in patients with allergic rhinitis.Allergy. 1984; 39: 509-514Crossref PubMed Scopus (13) Google ScholarWe would note, nonetheless, the marked degree of OKT8 reduction (and high ratio), more marked than usually reported in cases with respiratory allergy. It is possible, nonetheless, that this may be associated with the allergic condition underlying our patients illness, albeit of a more marked degree than is usual.Thank you for your letter. To the Editor: We agree that the literature cited demonstrates changes in T-cell subpopulations as suggested with decreased OKT8, although unlike Justribo et al, other authors1Kus J Tse KS Enarson D Grzybowski S Chan-Yeung M Lymphocyte subpopulations in patients with allergic rhinitis.Allergy. 1984; 39: 509-514Crossref PubMed Scopus (13) Google Scholar, 2Kus J Tse KS Vedal S Chan-Yeung M Lymphocyte subpopulations in patients with allergic and nonallergic asthma.Clin Allergy. 1985; 15: 523-529Crossref PubMed Scopus (20) Google Scholar do not observe decreased OKT4 and therefore report an increased OKT4/OKT8. We would further agree that this appears to be markers of respiratory allergy and note the evidence that, with treatment of the allergy, improvement toward normal can be observed in these parameters.1Kus J Tse KS Enarson D Grzybowski S Chan-Yeung M Lymphocyte subpopulations in patients with allergic rhinitis.Allergy. 1984; 39: 509-514Crossref PubMed Scopus (13) Google Scholar We would note, nonetheless, the marked degree of OKT8 reduction (and high ratio), more marked than usually reported in cases with respiratory allergy. It is possible, nonetheless, that this may be associated with the allergic condition underlying our patients illness, albeit of a more marked degree than is usual. Thank you for your letter. T-lymphocyte Subpopulations in Patients with Respiratory AllergyCHESTVol. 91Issue 2PreviewTo the Editor: Full-Text PDF