TLRs expression dynamics in patients with herpes-associated erythema multiforme due to immunotherapy

Abstract

Event Abstract Back to Event TLRs expression dynamics in patients with herpes-associated erythema multiforme due to immunotherapy Olga V. Lebedinskaya1*, Ekaterina A. Sorokina2, Nelly K. Akhmatova2 and Svetlana Skhodova2 1 Acad. E.A. Wagner Perm State Medical Academy, Russia 2 I.I. Mechnikov Research Institute for Vaccines and Sera RAMS, Russia Herpes-associated erythema multiforme (GAEM) is the most common form among erythemas. Long-term virus persistence in the body leads to development of secondary immunodeficient states. Defects in the mechanisms of recognition of various microbial PAMPs by TLRs expression changes may impair the immune response. The aim of investigation was to study the TLRs expression on PBMC and in the skin of GAEM-affected patients and dynamics of these indicators in the course of therapy. TLRs expression levels were determined by flow cytometry. In study of 39 GAEM-affected patients there was observed high TLRs level in their sera, which confirms the obvious role of viruses in the pathogenesis of dermatosis. In patients with disease duration of less than 6 months there were low values of TLR2 (up to 0.05%) and TLR4 (0.1%) due to increased expression of TLR3 (up to 96.7%) and TLR9 (up to 97.8%). In patients with combined GAEM HSV1 and HSV2 infection in the form of recurrent facial herpes and genital herpes the expression levels of TLR4 and TLR9 in the sera were by 4-fold greater than the values of healthy subjects. Immunovac-VP-4 therapy favored to increase the TLR2, 3,9 expression in sera. Overexpression of these TLRs may be a laboratory marker of the outbreak, the severity of infection and the effectiveness of the therapy. Along with the appointment of antiviral complex the therapy with immunomodulators restores cell cooperation in the immune response of GAEM-affected patients. This work was supported by RFBR grant №11-04-96037r_ural_a and administrative body of Perm Region. Keywords: Herpes-associated erythema multiforme, TLRs expression, immunomodulators, antiviral, dermatosis Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Innate immunity Citation: Lebedinskaya OV, Sorokina EA, Akhmatova NK and Skhodova S (2013). TLRs expression dynamics in patients with herpes-associated erythema multiforme due to immunotherapy. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00851 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Ms. Olga V Lebedinskaya, Acad. E.A. Wagner Perm State Medical Academy, Perm, Russia, lebedinska@mail.ru Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Olga V Lebedinskaya Ekaterina A Sorokina Nelly K Akhmatova Svetlana Skhodova Google Olga V Lebedinskaya Ekaterina A Sorokina Nelly K Akhmatova Svetlana Skhodova Google Scholar Olga V Lebedinskaya Ekaterina A Sorokina Nelly K Akhmatova Svetlana Skhodova PubMed Olga V Lebedinskaya Ekaterina A Sorokina Nelly K Akhmatova Svetlana Skhodova Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.