Abstract
Titration is a method of quantitative/chemical analysis which can be used to determine the concentration of a known reactant. Mixed solvency has been widely used to enhance the aqueous solubility of a large number of poorly water-soluble drugs. Various organic solvents like methanol, chloroform, dimethyl formamide and ethanol have been employed for solubilization of poorly water-soluble drugs. Organic solvents because of their higher cost, toxicities and pollution are not used as solvent. In the present investigation a sodium benzoate, sodium citrate, sodium salicylate solution (an economic agent) was employed as a hydrotropic solubilizing agent to solubilize the poorly water-soluble drug aceclofenac for its titrimetric analysis in bulk sample and tablets precluding the use of organic solvent. The proposed method is new, simple, precise and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method.
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