Abstract
AbstractA new approach is demonstrated for the synthesis of macrotetralides through an olefin metathesis reaction using Grubbs' second‐generation catalyst with titanium isopropoxide as a cocatalyst. This study demonstrates a tandem self‐cross and ring‐closing metathesis approach to form macrocyclic ring systems with excellent (E) selectivity. The reaction was optimized with regard to functional group, catalyst, solvent, Lewis acid, concentration, and temperature.
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