Abstract
Calcium- and voltage-gated K+ channels of big conductance (BK) regulate cerebral artery smooth muscle (SM) contraction. BK complexes include tissue-specific accessory subunits (beta1-4, encoded by KCNMB1-4) that embolden BK currents with distinct kinetic and pharmacological phenotypes. Beta1 is predominant in SM where it increases the BK’s apparent calcium sensitivity. Moreover, while cholesterol (CLR) inhibits homomeric BK made of channel-forming alpha subunits, beta1 subunit-including BKs are activated by this sterol via up-regulation of beta1 levels in the plasma membrane of cerebral artery SM cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
