Abstract
BackgroundCinnamomi Cortex, the dried stem bark of Cinnamomum cassia Presl (Rougui in Chinese) has been widely used in traditional Chinese medicine, cooking and perfumery for thousands of years. Traditionally, the Cinnamomi Cortex of thick size is considered to be of good quality; however, there is no scientific data to support this point. Considering that essential oils are the main bioactive components, Cinnamomi Cortex of greater variety and amount essential oils is thought to be of better quality. In this study, laser microdissection coupled with ultra-high performance liquid chromatography-quadrupole/time-of-flight-mass spectrometry (UPLC-Q/TOF–MS) was applied to profile the essential oils in different tissues of Cinnamomi Cortex and to determine if there is a correlation between the essential oil content and the stem bark thickness.ResultsWe report the tissue-specific metabolic profiles of different grades of Cinnamomi Cortex. Nineteen chemical components were unequivocally or tentatively identified in the chromatogram of the test samples. The results indicate that the bioactive components, the essential oils, were mainly present in the phloem.ConclusionPhloem thickness is the key character for evaluating the quality of Cinnamomi Cortex. Our results can be of great importance in improving the cultivation, harvesting, and processing of Cinnamomi Cortex, as well as enhancing its effects in clinical applications.
Highlights
Cinnamomi Cortex, the dried stem bark of Cinnamomum cassia Presl (Rougui in Chinese) has been widely used in traditional Chinese medicine, cooking and perfumery for thousands of years
Various specifications of different grades of Cinnamomi Cortex have been found in the herbal market, Zhou et al Chemistry Central Journal (2018) 12:71 such as Zhong tong, Ban gui, and Guan gui
They are typically used without discrimination, but is there a clinical difference? Comparing the chemical composition of different grades will enable us to determine the difference between grades and will help us evaluate whether these differences are significant in terms of applications
Summary
Cinnamomi Cortex, the dried stem bark of Cinnamomum cassia Presl (Rougui in Chinese) has been widely used in traditional Chinese medicine, cooking and perfumery for thousands of years. Cinnamomi Cortex, is the dried stem bark of Cinnamomum cassia Presl, known as Rougui in Chinese It has been widely cultivated in Southeast Asia and is commonly used in pharmaceuticals, cooking and cosmetics. Various specifications of different grades of Cinnamomi Cortex have been found in the herbal market, Zhou et al Chemistry Central Journal (2018) 12:71 such as Zhong tong (cylindric as sample RGgxdxzt), Ban gui (plate-like as sample RGgxpnbg), and Guan gui (scroll-like or groove shape as sample RGgxpngg). In clinical applications, they are typically used without discrimination, but is there a clinical difference? The research provides helpful information that can guide the cultivating, collecting and processing of Cinnamomi Cortex for maximum quality in applications
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