Abstract
Surgical site infections (SSIs) remain a devastating complication following cardiac surgery. Prophylactic antimicrobials administered at the time of surgery are one of the most important strategies for preventing SSIs. This research aimed to improve understanding of how to best prevent SSIs and ensure responsible, evidence-based use of antimicrobials. Cardiac surgery infection occurs in bone, subcutaneous and deep tissue; blood is not the most important compartment when considering antibiotic levels required to provide optimal surgical site prophylaxis. It was hypothesised that current Australian Therapeutic Guidelines: Antibiotic recommendations have led to suboptimal tissue cefazolin (CFZ) levels. This study was funded by the Robin Smallwood Bequest awarded by ANZCA.
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