Abstract
mice. These findings were confirmed by inhibiting the P2X7 receptor with oxi-ATP (40 mg/kg i.p.). Inhibition of P2X7 receptors led to increased bacterial burden, cytokine and chemokine levels in septic shock. P2X7KO/P2X7WT bone marrow chimeras exhibited higher cytokine and chemokine levels than P2X7WT/P2X7WT mice. Septic P2X7KO mice had excessive apoptosis in the thymus and increased inflammation in the heart and lung.
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