Abstract
Research advances in tissue immunology have begun to decipher how organ physiology is integrated with resident immune cells during tissue development, healthspan and disease states. Here, we review a selection of studies from 2019 that highlight how resident lymphocytes communicate with epithelia, neurons and stromal cells in tissues to coordinate regional and systemic remodelling in response to local perturbations. Several studies from 2019 have highlighted emerging routes of communication between tissue-resident immune cells and local neurons, stromal cells, endothelial cells and epithelial cells to exert effects beyond the local tissue.
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