Abstract
Tissue engineering is making great strides to repair disease and damage in a wide range of tissues, many of which are high profile and well documented. However, the thymus and secondary lymphoid organs are tissues which have not received significant attention from the research community but are nonetheless important targets for tissue engineering based therapies. These organs are fundamental in developing and maintaining the mammalian immune system and create environments for antigen screening and pathogen removal. This review discusses the function of these organs with reference to tissue development, tissue resident progenitor cells and disease. Subsequently strategies utilised for tissue engineering and regeneration are discussed in conjunction with methods to replicate their function and alternative methods to generate progenitor cells.
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