Abstract
Nowadays, the common treatment of urethral stricture is substitute urethral reconstruction using a buccal mucosa graft or an acellular matrix. However, most studies showed that their use can cause the development of fibrosis, recurrent stricture, necrosis, and graft rejection (Atala et al., 2017). Therefore, this study aimed to fabricate a tissue-engineered urethral wall construct and test it in preclinical and clinical trials. We developed a system from mechanically strong hybrid matrix from collagen and glycolide and L-lactide fibers and spheroids from buccal epithelial cells. Epithelial cell in spheroids could save their phenotype and form epithelial lining on a matrix surface. The developed construct successfully passed preclinical trials (rabbits); and we have initiated its clinical trials (NCT03205670). Thus, this tissue-engineered construct is promising; and after ending trials, its use can be easily translated into clinical practice.
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