Tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol and its metabolites in pigs after oral exposure

Abstract

The tissue distribution and bioaccumulation of 8:2 fluorotelomer alcohol (8:2 FTOH) were evaluated in pigs after oral exposure of a dose of 5 mg/kg.b.w.d. for 7 d. The bioaccumulation of 8:2 FTOH and its metabolites showed significant differences among the various tissues. The parent compound was quickly depleted, and the main metabolites perfluorooctanoic acid (PFOA), perfluoroheptanoic acid (PFHpA), and 3-perfluoroheptyl propanoic acid (7:3 FTCA) were detected in all tissues examined. The relative elimination half-life (T1/2re) calculated by compound concentration of 7:3 FTCA and PFOA was longest in kidney tissue (8.60 and 23.9 d, respectively), while their absolute elimination half-life (T1/2ab) of 7:3 FTCA and PFOA calculated by compound amount was longest in kidney tissue (10.41 and 64.1 d, respectively). The T1/2re and T1/2ab for PFHpA was longest in heart tissue (19.3 d and 30.26 d, respectively).The accumulated PFOA in kidney and liver tissues was still above the detection limit (LOD) at 21 d postdosing. These results indicate that PFOA and the kidneys are the ideal biomonitoring marker and target tissue, respectively, for 8:2 FTOH pollution. The T1/2 values of the main metabolites were of long duration compared to the growth cycle of farmed pigs (approximately 180 d) before slaughter; therefore, pigs contaminated with 8:2 FTOH present a potential risk to humans.