Abstract
A daily rhythm of liver microsomal enzyme activity and plasma corticosterone levels with a minimum during the light period and a maximum in darkness was found in rats. Treatment with α-methyl-tyrosine consistently increases the plasma corticosterone concentrations and abolishes the fluctuations of microsomal enzyme activity. Intraventricular or intravenous injection of 6-OH-dopamine does not modify the fluctuation of the corticosterone levels nor the enzymatic activity of the microsomes at the different times of the day. The relationship between the brain catecholamine availability and the daily rhythm of drug metabolism is discussed.
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