1- https://doi.org/10.1016/j.vaccine.2024.126617
Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants.
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SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link. We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant. In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102days [IQR 48-178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection. SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.
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Supplemental Digital Content is available in the text.
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