Abstract
The development of automatic instrumentation for ambulatory blood pressure monitoring makes it possible to follow the time-course of blood pressure variation over 24h or more in large groups of individuals. Whenever samples from a reference group of individuals are available, one may construct a prediction interval that is expected to include any single future observation from the reference population, with a specified confidence. Alternatively, the reference interval may consist of a tolerance interval that will include at least a specified proportion of the population with a stated confidence. To examine prospectively whether a new, combined tolerance-hyperbaric test approach of establishing tolerance intervals for the circadian variability of blood pressure as a function of gestational age and then computing the hyperbaric index as a measure of blood pressure excess provides high sensitivity and specificity in the early identification of pregnant women who subsequently will develop gestational hypertension or pre-eclampsia. We used data sampled for 48 h from 148 normotensive men and women to compute and compare time-specified tolerance and prediction intervals for blood pressure. Once the threshold, given by the upper limit of the tolerance interval, was available, the hyperbaric index, as a measure of blood pressure excess, could be calculated by numerical integration as the total area of any given patient
Published Version
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