Abstract
BackgroundHuman papillomavirus (HPV) is a common sexually transmitted pathogen and the cause of several cancers and of anogenital warts. With this study, we estimated the trend of hospitalizations for anogenital warts (AGWs) in the Veneto region (Italy) from 2007 to 2018.MethodsThe analysis included all the hospital discharge records of public and accredited private hospitals occurred in Veneto residents in the timespan 2007–2018. The ICD9-CM code 078.11 considered were those associated with condyloma acuminatum and those associated with surgical interventions for vulval/vaginal warts, penile warts anal warts. Annual total and sex- and age-specific hospitalization rates and trends were calculated and correlated with the different HPV vaccine coverage over the study period.ResultsWe observed an overall reduction of hospitalization rates for AGWs: from 15.0 hospitalizations every 100,000 Veneto residents in years 2007–08 to 10.9 hospitalizations every 100,000 Veneto residents in year 2017–18 (− 37.4%; p < 0.05). Reduction has been caused by a drop in hospitalizations in females - from a rate of 20.4/100,000 in 2007–2008 to a rate of 10.8/100,000 in 2017–18 (AAPC: -7.1; 95%CI: − 10.6;-3.4); while in males, we observed a slight - but not statistically significant - increase in hospitalization rates.ConclusionThe marked decline in hospitalization rates for AGWs in Veneto Region is probably attributable to the high coverage rates of HPV vaccination programs implemented since 2008.
Highlights
Human papillomavirus (HPV) is a common sexually transmitted pathogen and the cause of several cancers and of anogenital warts
From 1 January 2007 to 31 December 2018, 6977 hospitalizations related to an anogenital warts (AGWs) diagnosis in one of the primary or secondary fields were registered, 104 of them have been excluded from the analysis being repeated admissions
In the time period of the analysis, we observed an overall reduction of hospitalization rates for AGWs: from 15.0 hospitalizations every 100,000 Veneto residents in years 2007–08 to 10.9 hospitalizations every 100,000 Veneto residents in year 2017–18 (− 37.4%; p < 0.05)
Summary
Human papillomavirus (HPV) is a common sexually transmitted pathogen and the cause of several cancers and of anogenital warts. We estimated the trend of hospitalizations for anogenital warts (AGWs) in the Veneto region (Italy) from 2007 to 2018. Human papillomavirus (HPV) is one of the most frequently sexually transmitted viruses in the world. Veneto Region started to provide HPV vaccination with the quadri-valent vaccine for free and with an active-call system to females of 12 years of age in 2008 [6]; from 2014 the vaccination has been extended to males [7] and from 2017 the gender-neutral vaccination has been practiced with the nine-valent vaccine [8]. Patients undergo hospitalization only in the most severe and complex cases that require surgical excision of the AGWs [13]
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